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Precision Medicine for Neurovascular Lesions

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Mission

NuVasc is building the first precision-medicine platform for neurovascular lesions including brain arteriovenous malformations (bAVM) and aneurysms. We use endovascular-enabled molecular genomics and targeted therapeutics to change how neurovascular lesions are diagnosed, risk-stratified, and treated.

Medical illustration showing brain AVM biopsy methods, gene editing of KRAS mutations, targeted drug therapies, and treated AVM vessels.

The Problem

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Brain AVMs are the leading cause of hemorrhagic stroke in children, & can lead to permanent neurologic disability or death

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Treatment options are limited to brain surgery (requiring long hospitalization, if ruptured) or radiation therapy 

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Many of the underlying biological pathways that cause brain AVMs have been implicated in cancer

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Pharmacological treatment of brain AVMs is not in use because there is no standard for genomic diagnosis of AVMs

Scope: 18 in 100,000 people have a brain AVM and 1 in 50 people have an intracranial aneurysm

The Problem

Treatments are currently limited to high-risk craniotomy or radiation therapy, and risk of non-treatment is death or permanent disability

Mutations in cerebrovascular lesions overlap with well-characterized targets in oncology (KRAS, BRAF, MEK, PI3KCA, etc.)

Precision therapies exist, but clinicians lack a safe, reliable way to determine which patients will benefit

Millions of patients have neurovascular lesions eligible for targeted therapies, with 50,000+ AVMs and over 1 million aneurysms in the US

Our Solution

Targeted Therapeutic Program
First precision medicine treatment for brain AVMs
  • Targets validated genetic drivers already drugged in oncology
  • Supported by human AVM clinical responses to MEK and KRAS inhibitors
  • Lead asset: In-licensed KRAS G12D inhibitor
  • Pursuing orphan and rare-disease FDA pathways

Companion Genomic Diagnostic
Endovascular and liquid biopsy to identify gene mutations
  • Patented endoluminal and liquid biopsy
  • Enables precise patient selection and response monitoring
  • Designed as a companion diagnostic for NuVasc’s therapeutic trials

Built for Clinical Adoption
Endovascular and liquid biopsy to identify gene mutations
  • Integrated into standard neurointerventional workflows
  • No craniotomy required for molecular diagnosis
  • Scalable across leading academic and referral centers

Partners

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Zac

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Andy

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Kris

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Resources

The Bee Foundation logo with text 'The Bee Foundation for Brain Aneurysm Prevention' and a stylized bee illustration.

Bee Foundation

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The Aneurysm and AVM Foundation logo featuring a stylized person with outstretched arms encircled by a maroon curve.

The Aneurysm and AVM Foundation

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Logo of Pediatric Section showing a child's head silhouette with a brain illustration inside, encircled by text 'Pediatric Section AANS / CNS'.

AANS/CNS Section on Pediatric Neurosurgery

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Logo of the AANS CNS Cerebrovascular Section featuring a red blood vessel over a brain's blood vessel network, with the year 1981 below.

AANS/CNS Section on Cerebrovascular Neurosurgery

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CHOP Neuroscience Accelerator

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Joe Niekro Foundation logo featuring a stylized red brain above the foundation name in red capital letters.

Joe Niekro Foundation

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The Bee Foundation

The mission of The Bee Foundation is to raise awareness of brain aneurysms and increase funding for innovative research that changes lives.

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Journal of Neurosurgery Report

"An opportune time for targeted brain arteriovenous malformation therapy"

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Contact

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